COVID-19 (SARS-CoV-2) Main Protease
COVID-19 protease with bound inhibitor

COVID-19 protease with bound inhibitor

Close up of bound inhibitor in space-filling (CPK) representation

Close up of bound inhibitor in space-filling (CPK) representation

Global View - Stick Representation

Global View - Stick Representation

Global View - CPK Representation

Global View - CPK Representation

Global View with Surface - Interactive

Closeup of Inhibitor Interactions - Interactive

COVID-19 Main Protease (Semitransparent) - Interactive Sketchfab

COVID-19 (SARS-CoV-2) Main Protease

This is the structure of the COVID-19 (SARS-CoV-2) main protease (PDB accession 6LU7) that plays an essential role in processing the proteins that are translated from the viral RNA. Inhibition of this protease would halt viral replication and this protein represents one of the best drug targets for developing new treatments for COVID-19 infection. The structure shown shown here is bound to an alpha-ketoamide peptide mimetic inhibitor. The dashed lines indicate drug-protein interactions (green = hydrogen bond, yellow = carbon-hydrogen bond, pink = hydrophobic, magenta = pi-pi interactions).

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