Global View with Surface - Interactive
Closeup of Inhibitor Interactions - Interactive
COVID-19 Main Protease (Semitransparent) - Interactive Sketchfab
This is the structure of the COVID-19 (SARS-CoV-2) main protease (PDB accession 6LU7) that plays an essential role in processing the proteins that are translated from the viral RNA. Inhibition of this protease would halt viral replication and this protein represents one of the best drug targets for developing new treatments for COVID-19 infection. The structure shown shown here is bound to an alpha-ketoamide peptide mimetic inhibitor. The dashed lines indicate drug-protein interactions (green = hydrogen bond, yellow = carbon-hydrogen bond, pink = hydrophobic, magenta = pi-pi interactions).